How DUROLANE works

Osteoarthritis (OA) is the result of mechanical, cellular, and biochemical processes.

Healthy cartilage, which is composed of water, collagen, and proteoglycans, continually remodels itself as chondrocytes replace macromolecules lost through degradation. OA disrupts this process, leading to increased degeneration and an abnormal repair response.¹⁹ The pathophysiology of OA involves a combination of mechanical, cellular, and biochemical processes.¹⁹

DUROLANE is a stabilized hyaluronic acid (HA), from a non-animal source, therapy for the intra-articular treatment of mild to moderate osteoarthritis in joints of all sizes.²

DUROLANE uses advanced and unique NASHA technology which gives it a unique gel bead structure. The patented stabilization technique ensures that the naturally cross-linked and entangled HA network is kept in place by introducing a very limited number of synthetic cross-links, resulting in minimal modification.⁸

NASHA structure
Entanglement of HA chains (natural cross-links)

BDDE (1, 4 butanediol diglycidyl ether) Linker

Summary of Indications for Use
DUROLANE (3ml): Symptomatic treatment of mild to moderate knee or hip osteoarthritis. In addition, DUROLANE has been approved in the EU for the symptomatic treatment associated with mild to moderate osteoarthritis pain in the ankle, shoulder, elbow, wrist, fingers, and toes.

DUROLANE SJ (1ml): Symptomatic treatment associated with mild to moderate osteoarthritis pain in the ankle, elbow, wrist, fingers, and toes.

Both DUROLANE and DUROLANE SJ are also indicated for pain following joint arthroscopy in the presence of osteoarthritis within 3 months of the procedure.

There are no known contraindications.

You should not use DUROLANE if you have infections or skin disease at the injection site. DUROLANE has not been tested in pregnant or lactating women, or children.

Risks can include transient pain, swelling and/or stiffness at the injection site.

Full prescribing information can be found in product labeling.

© 2019 Bioventus LLC.
DUROLANE, Bioventus and the Bioventus logo are registered trademarks of Bioventus LLC. NASHA is a registered trademark of Galderma S.A.

^{*First introduced in the European Union in 2001.}

To learn more about DUROLANE or for contact information, please select your location to continue.

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