- DUROLANE was shown to have a half-life of 4 weeks or 32 days in the joint following a single injection.3,6
- DUROLANE has a longer half-life than cross-linked and unstabilized hylan G-F 20 (Synvisc® and Synvisc-One®).4,5
Graphs based on elimination of hyaluronic acid (HA) from the joint space of rabbits as a function of time for DUROLANE6 as compared against extrapolated data for the residence time of hylan G-F 204 and low molecular weight HA5 in a similar rabbit model. DUROLANE values calculated based on projected clearance of one-3 mL injection (20 mg/mL). Hylan G-F 20 values calculated based on projected clearance of one-6 mL injection (representing Synvisc-One®) or three-2.0 mL injections (representing Synvisc-3 injection regimen) of HA at 16 mg/mL in a rabbit model.4 As shown in the graph, DUROLANE human data correlates well with the rabbit model.3