DUROLANE is created using NASHA – an advanced, patented hyaluronic acid (HA) production process. DUROLANE is a highly purified product, manufactured without any animal-sourced materials, ensuring that the risk of contaminants or impurities is close to zero. Since the introduction of DUROLANE in 2001, there have been no reports or instances of immunological or anaphylactic reactions.
DUROLANE is the only HA treatment for osteoarthritis (OA) pain that is based on NASHA. NASHA technology is a production process involved in the creation of a number of medical products that use this unique HA formulation and its properties to provide healthcare solutions.
- The NASHA process uses bacterial fermentation followed by a purification process, to obtain natural HA with a high degree of purity.
- Potentially harmful components, such as proteins and endotoxins are minimized and the non-animal process excludes the possibility of any contaminants of animal origin.
- The molecular stabilisation of the NASHA process increases the residence time of HA, which normally has a very short half-life in the joint.
- The stabilisation process of NASHA results in less than 1% modification of HA, where covalent bonds are created to link the HA molecules together.1