Osteoarthritis (OA) is the result of mechanical, cellular, and biochemical processes.
Healthy cartilage, which is composed of water, collagen, and proteoglycans, continually remodels itself as chondrocytes replace macromolecules lost through degradation. OA disrupts this process, leading to increased degeneration and an abnormal repair response.19 The pathophysiology of OA involves a combination of mechanical, cellular, and biochemical processes.19
DUROLANE is a stabilized hyaluronic acid (HA), from a non-animal source, therapy for the intra-articular treatment of mild to moderate osteoarthritis in joints of all sizes.2
DUROLANE uses advanced and unique NASHA technology which gives it a unique gel bead structure. The patented stabilization technique ensures that the naturally cross-linked and entangled HA network is kept in place by introducing a very limited number of synthetic cross-links, resulting in minimal modification.8
Entanglement of HA chains (natural cross-links)
BDDE (1, 4 butanediol diglycidyl ether) Linker